Chorioamnionitis and Its Risk to Babies June 27, 2013/in Video Blog by Birth Injury Justice Chorioamnionitis and Its Risk to BabiesWe’ve already talked about the risk of sepsis. Sepsis can certainly occur in chorioamnionitis. And the ultimate risk of sepsis to the baby, and unfortunately is very common, is fetal loss, fetal demise, or miscarriage. More likely or more frequently is the phenomena of chorioamnionitis and funisitis. And there are a couple things that can happen in chorioamnionitis. The most likely theory is that when, especially the fetal side of the amniotic sac becomes infected, it triggers an inflammatory response in the fetus. Not the mother, but the fetus. So the fetus begins to release large quantities, massive quantities, of inflammatory markers, cytokines, interleukin, tissue necrosis factor. And the importance of those is that those are particularly toxic to brain cells. It will kill the brain cells. So children that end up with this inflammatory response as a result of chorioamnionitis will have defuse, widespread white brain matter loss in the brain. In funisitis, you can also get the inflammatory response, so it’s somewhat of a double whammy. You can end up with the same type of white matter damage as a result of the inflammatory response to funisitis. But you can also, in very severe cases of funisitis, actually have damage to muscle cells in the walls of the vessels in the cord. So again, you usually have two veins and one artery in the cord, which is feeding the baby nutrients and oxygen and taking away waste products. And what happens when the funisitis actually damages the cord, it decreases the profusion to baby, the delivery of oxygen and nutrients. And you can end up with widespread and very profound brain damage as a result of funisitis.